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Identification and characterization of PDC1, a novel protein involved in the epigenetic cell degeneration Crippled Growth in Podospora anserina

Abstract : The model fungus Podospora anserina exhibits Crippled Growth (CG), a cell degeneration process linked to the spreading of a prion-like hereditary element. Previous work has shown that the PaMpk1 MAP kinase and the PaNox1 NADPH oxidase are key player in setting up CG. Here, we identified PDC1, a new gene that negatively regulates the PaMpk1 pathway, by identifying the gene mutated in the PDC2205 mutant. This mutant exhibits strong CG in conditions where the wild-type does not. PDC1 encodes a small protein conserved in other Pezizomycotina. The protein contains four evolutionary-conserved cysteines, a tryptophan and a histidine; all six amino-acid are essential for function. PDC1 is located in the cytosol and is present in lower amounts in stationary hyphae in accordance with its role as a repressor. Epistasis analyses place PDC1 between PaMpk1 and PaNox1.
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https://hal-univ-paris.archives-ouvertes.fr/hal-03152339
Contributor : Nadia Berkoun <>
Submitted on : Thursday, February 25, 2021 - 3:05:37 PM
Last modification on : Thursday, July 8, 2021 - 3:51:07 AM

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Tinh-Suong Nguyen, Herve Lalucque, Philippe Silar. Identification and characterization of PDC1, a novel protein involved in the epigenetic cell degeneration Crippled Growth in Podospora anserina. Molecular Microbiology, Wiley, 2018, 110 (4), pp.499-512. ⟨10.1111/mmi.14096⟩. ⟨hal-03152339⟩

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