, En fait, l'acide tiénilique et l' i pronia zide condui sent à l' appa rition d'anticorps anti -tissus très spécifiques , n on rencontrés dans d'autres types d'hépatites. Cela renforce l'idée que le cytochrome P-450-8 . . . et la MAO B sont non seulemen t reconnus par l es anticorps anti-LKMZ ou anti-M6 mais seraient éga lement les antigènes responsables de l' appar ition des ces anticorps in v i vo

, il a é t é récemment étab li que l es anticorps anti -LKMl, dé t ectés dans l e sérum de ces patient s , r econnai ssent un cytochrome P-450 de foie humain, l e cy tochrome P-450-buf I ou II (77) ou dbl (78) de la sous -famille IID. Toutefois, dans ces hépatite s, Le problème s'avère plu s comple x~ dans le cas d'autres hépatites de type immune-allergique. Ainsi , dans les hépatites chroniques ac ti ves (CAH)

, les anticorp s anti-ADN détectés dans le sér um de ces ma l ades réa gissent non seu l ement avec l'ADN mai s au ss i avec des phospholipides et une protéine membranaire (109), Dan s l e cas du lupus éryth émateux diss éminé (SLE )

, Il a éga l ement é t é propo sé que des v1rus soient la cau se de certain es réac tions auto-immunes, s oit par l'expression d' an ti gè nes vir aux à l a su rfa ce de cellules i nfectées, soit par le biai s d ' auto -anticorps anti -virus dont les id i ot ype s peuvent donner li eu à des réactions croi sées avec certains

, Une autre hypothèse pour l' appa rition d'auto-anticorp s s circulantes (monocy t es , neutrophi l es). L'inte r action du médicament et d e ces cel lul es conduit à l a présentation d 'un néo -antigène par ces cel lul es , pui s à la production d ' antico rp s par l

. B-i-b-l-i-0-g-r-a-p-h-i-e-===============,

. A. Mackay-i, 5) Induction by drugs of hepatitis and autoantibodies to cell organelles : significance and interpretation, Hepatology, ~', vol.5, pp.904-906

M. Blour, . Poupon-r, Y. Calmus, J. D. Grange, J. D. Hamel et al., Hépatotoxicité des médicaments, Gastroenterol. Clin. Biol, vol.12, pp.48-60, 1988.

J. P. Benha1\10u, Drug~induced hepatitis : clinical aspects. Liver cells and drugs, Ed. A. Guillouzo. Coll. INSERM, vol.16, issue.4, pp.3-12

J. M. Neuberger, J. G. Kenna, and . Williams-r, Halothane hepa titis : attempt to develop an animal model, Int. J. Immunopharmacol.,~, vol.2, pp.123-131, 1987.

J. J. Luciano, . C. Raymond-gelle-m, and . D. Hoang-w, Hépatites médicamenteuses : mise au point, 1986.

L. M. Médecine-du-sud-est and . Xxii, , vol.6, pp.10472-10477

. Pessayre-d and . Larrey-d, 8 ) Mechanisms of drug-induced hepatitis. Liver cells and drugs, Ed. A. Guillouzo. Coll. INSERM, vol.164, pp.129-142

. K. Park-b, J. W. Coleman, and N. R. Kitteringham, Drug disposition and drug hypersensibility, Biochem. Pharmacol., ~', vol.5, pp.581-590, 1987.

Y. Calmus, . Bi-our-m, and . Poupon-r, 7) Les tests in vitro dans le diagnostic de s hépatites médicament eu s e s . Gast r o en t e r o l, Cl in . Biol, p.11

. P. Guengerich-f and D. C. Liebler, Enzymatic activ ation of chemicals to to x ic me tabolites, 1985.

, Crit. Rev. Toxicol., li, vol.3, pp.259-307

. Mansuy-d, Activation des composês organiques exogène s par les cytochromes P-450, 1979.

. C. Mueller-g and J. A. Miller, The metabolism of 4-dimethylamino-azobenz en e by r a t liver homogenates, J . Biol. Chem, vol.176, pp.535-544, 1948.

. C. Mueller-g, J. A. Miller, and . Glassner-m, The metabolism of methylated aminoazo dye s, 1953.

, J. Biol. Chem, vol.202, pp.579-587

. B. Brodie-b, J. R. Gilette, . La, and . N. Du-b, Enzymatic metabolism of drugs and e ther fore i gn c omp ounds, Annu. Rev. Biochem, vol.27, pp.42-49, 1958.

. Klingenberg-m, Pigment~ of rat liver microsomes, Arch. Biochem. Biophy s, vol.75, pp.376-414, 1958.

. Garfinke_l-d, 8) Studies on pig liver microsomes. I. Enzymatic and pigment composition of different microsomal fractions, Arch. Biochem. Biophys, vol.77, pp.493-509

. Omura-t and . Sato-r, The carbon monoxide-binding pigment of live r microsome s . II. Solubilization, pur ification and prope rt ies, J. Biol. Chem, vol.239, pp.2379-2385, 1964.

. Ruckpaul-k and . Bernhardt-r, Biochemical aspects of the monooxygenas e sy stem in the R.E . of mammalian liver, pp.11-57, 1984.

. B. Okey-a, . A. Roberts-e, . A. Harper-p, and M. S. Denison, Induction of drug-metabolizing enzymes : mechanisms and consequences, Clin. Biochem, vol.19, pp.132-141, 1986.

. W. Nebert-d, . R. Nelson-d, M. Adesnik, . J. Coon-m, . Estabrook-r.~ et al.,

. Kemper-b, . Levin-w, . R. Philipps-i, . Sato-r, and M. R. Waterman, , 1989.

, The P-450 superfamily : updated listing of all genes and recommended nomenclature for the chromosomal loci, vol.1, pp.1-13

. C. Wolf-r, , 1986.

, Cytochrome P-450s : polymorphie multi gene families involved in carcinogen activation, Trends Genet, pp.209-214

D. J. Waxman, Rat hepatic cytochrome P-450, 1986.

. D. Black-s and M. J. Coon, Comparative structures of P-450 cytoch romes, 1986.

F. P. Guengerich, Cyt. P-450 enzymes and drug metabolism, 1987.

, Progress in drug me tabolism, vol.10, pp.1-53

. P. Guengerich-f, G. A. Dannan, . T. Wright-s, . V. Martin-m, and L. S. Kaminsky, Purification and characterization of liver microsomal cytochrome P-450 : electrophoretic, spectral, catalytic and immunochemical properties and inducibility of 8-isozymes isolated ~rom rats tr~ated with PB or BNF, Biochemistry, vol.21, pp.6019-6025, 1982.

P. Beaune, C. Ged, T. Cresteil, J. P. Leroux, . Kremers-p et al., Human liver microsomal cytochrome P-450, Porphyrins and porphyrias. Y. Nordmann Ed. Coll. INSERM, issue.6, pp.13-17

. P. Guengerich-f, . R. Umbenhauer-d, . F. Churchill-p, . H. Beaune-p, . Bocker-r et al., , 1987.

, Xenobiotica, vol.12, pp.311-316

. T. Meier-u, P. Dayer, . J. Male-p, T. Kronbach, and . A. Meyer-u, Mephenytoin hydroxylation polymorphism : characterization of the enzymatic deficiency in liver microsomes of poor metabolizers phenotyped 1n vivo, Clin. Pharmacol. Ther, issue.l985, pp.488-494

. P. Wang-p, P. Beaune, . S. Kaminsky-l, . A. Dannan-g, . F. Kadlubar-f et al., Purific a tion and charact erization of six cytochrome P-450 isozymes from human li ver microsomes, 1983.

, J. Biol. Chem, pp.5375-5383

J. Gut, . T. Meier-u, T. Catin, and . A. Meyer-u, Mephenytoin-type polymorphism of drug oxidation purificati on and characterization of a human liver cytochrome P-450 isozyme catalysing microsomal mephenytoin hydroxylation, Biochem. Biophys. Act a, vol.884, pp.435-447, 1986.

. Shimada-t, . S. Misono-k, and F. P. Guengerich, Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxydative drug metabolism, 1986.

, J. Biol. Chem, vol.261, pp.909-921

. R. Umbenhauer-d, . V. Martin-m, . S. Lloyd-r, and F. P. Guengerich, , 1987.

, Cl oning an d sequ en ce determinat i on of a comp l eme n tary DNA ' s try, vol.26, pp.1094-1099

. A. Leo-m, J. M. Lasker, J. L. Raucy, . I. Kim-c, M. Black et al., Metabolism of retinol and retinoic acid by human liver cytochrome P-450 IIC8, Ar ch. Bi ochem. Biophys, vol.269, pp.305-312, 1989.

C. Ged, . R. Umbenhauer-d, . M. Bellew-t, . W. Bork-r, . K. Srivastava-p et al., Characterization of cDNAs, mRNAs and prote ins related to human liver microsomal cy tochrome P-450(S)-mephenytoin 4, 1988.

, Biochemistry, vol.II, pp.6929-6940

. Pessayre-d, Mécanisme des hépatites médicamenteuses, Med. Sei, pp.373-379, 1986.

. M. Roitt-i and . Doniach-d, Immunofluorescent tests for the detect i on of antibodies WHO booklet of immuno logic a l t echniques, pp.1-1, 1972.

J. C. Homberg, N. Abuaf, . Helmy--khalil-s, . Bi-our-m, . Poupon-r et al.,

M. Beaugrand, J. Toulet, G. Danan, and J. P. Benhamou, Drug -induced hepatitis associated with anticytoplasmic organelle autoantibodies, 1985.

, Hepa tol ogy, vol.2, pp.722-727

J. C. Homberg, C. Andre, and . Abuaf-n, A new anti-1iver-kidney microsome antibody (anti -LKM2) in tienilic acid-induce d hepatitis, Clin. Exp. Immunol, vol.55, pp.561-570, 1984.

J. C. Homberg, . Ste-ll-y-n, . Andreis-i, N. Abuaf, F. Saadoun et al., , 1982.

, A new antimitochondria1 antibody (anti-M6) in iproniazidinduced hepatitis, Clin . Exp. Immunol, vol.47, pp.93-102

. Boccaccio-f, P. Attali, J. Nataf, O. Ink, M. Fabre et al., Hépatite due à la dihydrala zine, 1987.

, Gastroenterol . Clin . Biol, p.614

J. L. Schmit, P. Gaucher, . A. Bi-gard-m, G. Rauber, B. Champigneulle et al., , 1985.

W. B. Simpson-b, L. Strunin, D. Doniach, J. Perrin, and . J. Appleyard-a, Unexplained hepatitis following h a l othane, Brit. Med . J, vol.1, pp.1171-1176, 1976.

D. M. , Toxic and immunological mechanisms in halothane hepatitis, 1983.

D. V. Parke, , pp.171-180

. Mansuy-d, 19 8 7) A chemica l approach to reactive metabolites. Drug Metabolism from Molecules to Man, pp.669-678

H. Satoh, . R. Gi-llette-j, H. W. Davies, . D. Schulick-r, and L. R. Pohl, Immunochemical evidence of trifluoroacety lat ed c ytochrome P-450 in the liver of halothane-treated rats, Mol. Pharmacol, vol.28, pp.468-474, 1985.

H. Satoh, Y. Fukuda, . K. Anderson-d, . J. Ferrans-v, . Gillette-j et al., Immunological studies on the mechanism of halothane -induced hepatotoxicity : immuno-histochemical evidence of trifluoroacet y l ated hepatocytes, 1985.

, J. Pharmacol. Exp. Ther, vol.233, pp.857-862

H. J. Zimmerman, J. H. Lewis, . G. Ishak-k, and W. C. Maddrey, Ticrynafen-associated hepatic injury analysis of 340 cases, 1984.

, Hepatology, i', vol.2, pp.315-323

. Mansuy-d, . M. Dansette-p, C. Foures, M. Jaouen, G. Moinet et al., , vol.19, p.4

, Biochem . Pharmacol, pp.1429-1435

. M. Dansette-p, C. Amar, . B. Smith-c, E. Neau, C. Pons et al., Hydroxylation of the thiophene ring in vitro the 5-hydroxylation of tienilic acid is cat~lysed by cytochrome P-4 50 in rat and human microsomes, 1988.

, Cytochrome P-450 biochemistry and biophysics

I. Schuster and F. Taylor, , pp.751-754

. M. Dansette-p, C. Amar, C. Pons, and . Mansuy-d, Oxidative activation of the thiophene ring by hepatic enzymes : hydroxylation and formationof electrophilic metabolites during metabolism of tienilic acid and its isomer by rat live r microsomes, Biochem . Pharmacol, 1989.

J. P. Lafay, Les atteintes hépatiques associées à l'anticorps antimicrosorne de foi e et de rein de typ e 2 ; rôle de l'acide tiénilique, 1981.

P. Beaune, . M. Dansette-p, D. Mansuy, L. Kiffel, . Finck-m.-amar-c et al., Human anti-endoplasmic reticulum auto-antibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug, Proc. Natl. Acad. Sei, pp.551-555, 1987.

. Cresteil-t, P. Beaune, P. Kremers, C. Celier, . P. Guengerich-f et al., Immunoquantification of epoxide hydrolase and cytochrome P-450 iso zymes in fetal and adult human live r microsomes, Eur . J. Biochern, vol.151, pp.345-352, 1985.

H. M. Pichat-l, Synthèse d ' un diurétique marqué au 14 c : acide dichloro, vol.2, p.3, 1976.

, J. Label Compound Radiopharm, pp.437-453

P. Beaune, J. P. Flinois, P. Kremers, and J. P. Leroux, Purification of a new cytochrome P-450 from human liver microsornes, Biochem. Biophys. Acta, vol.840, pp.364-370, 1985.

. Omura-t and . Sato-r, The carbon mono xide binding pigment of liver mi crosomes, J. Biol. Chem, vol.237, pp.13-75, 1962.

. H. Lowry-o, . J. Rosebrough-n, . L. Farr-a, and . J. Randall-r, Protein measurement with the felin phenol reagent, J. Biol. Chem, vol.193, p.265, 1961.

. Weyler-w and . Salach-j.~-i, Purification and properties of mitochondrial MAO type A f rom human placent a, J. Biol. Chem, vol.260, pp.24-13199, 1985.

. L. Bancells-l, D. Balsa, . Gomez-n, and M. Unzeta, Effects of nondenaturing zwitterionic detergent chaps, 3-(3-cholamidopropyl)dimethylammonio 1-propanesulfonate, on rat liver mitochondrial and microsomal MAO, Biochem. Pharmacol., ~', vol.15, pp.2539-2546, 1987.

. 6~, . Wallin-h, C. Schelin, . Tunek-a, and . Jergil-b, A rapid and sensitive method for determination of covalent binding of benzo(a)pyrene to proteins, Chem. Biol. Interac, vol.38, pp.109-118, 1981.

U. K. Laemmli, Cleavage of structural protein s during to assembly of the head of bacteriophage T4, 1970.

, Nature, vol.227, pp.680-685

H. T. Towbin, ·. Staei-ilin-t, and . Gordon-j, Electrophoretic transfer of proteins from polyacrylamid ge l on to nitrocellulose sheets applications. Pree. Natl; Acad, p.76, 1979.

. M. Hsu-s and . Soban-e, , 1982.

, Color modification of diarninobenzidine (DAB) precipitation by rnetallic ions and its application for doubl e i mmunochernistry

, J. Histochem. Cytochem, vol.30, pp.1079-1082

. F. Erlanger-b, F. Bôrek, . M. Be~jer-s, and . Lieberman-s, , 1957.

, Methods in cell b iology, J. Biol. Chem, vol.228, pp.29-83

. C. Wolf-r, S. Seilman, F. Oesch, . T. Mayer-r, and . D. Burke-m, Multiple forms of cytochrome P-450 related to forms induced marginally by phenobarbital, Biochem. J, vol.240, pp.27-33, 1986.

P. Beaune, . M. Dansette-p, D. Mansuy, L. Kiffel, C. Amar et al., Autoantibodies anticytochrome P-450 during autoimmune hepatitis. Liver ce1ls and drugs Ed, A. Guillouzo Coll. INSERM, vol.164, pp.175-180, 1988.

. J. Waxman-d, . P. Lapenson-d, M. Krishnan, . Bernard-0, . Kre-i-bich-g et al., , 1988.

, Antibodies to LKM1 in CAH recognize specifie forms of hepatic cytochrome P-450

, Gastroenterology, pp.1326-1331

. T. Bains-s, . M. Gardiner-s, K. Mannweiler, D. Gillett, and G. G. Gilson, Immunochemical study of the contribution of hypolipidaemic induced cytochrome P-452 to the metabolism of laurie acid and arachidonic acid, 1985.

, Biochem. Pharmacol., l±, vol.18, pp.3221-3229

N. E. , 19 8 6) Hydroxylation métabolique 1n vitro des acyl-2-thiophènes

D. E. De-pharmacochimie-moléculaire, P. Expérimentale, and . Métabolisme,

E. F. Gonzal, The molecular biology o f cytochro me P -450s, Ph armacol . Rev, vol.40, pp.243-271, 1989.

M. Gueguen, . Meunier-rotival-m, . Bernard-o, and . Alvarez-f, Anti-LKM antibody recognizes a cytochrome P-450 from the IID subfamily, 1988.

, J. Exp. Med, vol.168, pp.801-806

. Kiffel-l, J. Loeper, J. C. Homberg, and J. P. Leroux, A human cytochrome P-450 is recognized by anti-LKM antibodies in autoimmune chronic hepatitis, Biochem. Biophys. Res. Commun, vol.159, pp.283-289, 1989.

. M. Zanger-u, H. P. Hauri, J. Loeper, J. C. Homberg, and . A. Meyer-u, 88) Antibodies against human cytochrome P-450 db1 in autoimmune hepatitis type II, Proc. Natl. Acad. Sei, pp.8256-8260

H. Satoh, . M. Martin-b, . H. Schulick-a, . D. Christ-d, J. G. Kenna et al., Human anti-endoplasmic reticulum antibodies in sera of patients with ha1othane-induced hepatitis a re directed against a trifluoroacetylated carboxylesterase, Proc. Natl. Acad. Sei, pp.322-326, 1989.

. Hop-f-u, B. K. Meyer-zum, and A. W. , Détection of a liver-membrane autoantibody in HBsAgnegative CAH, N. Engl. J. Med, vol.294, pp.57-65, 1976.

G. Gerken, M. Manns, G. Ramadori, T. Poralla, H. P. Dienes et al., Liver membrane autoantibodies in CAH, J. Hepatology, vol.5, pp.65-74, 1987.

K. B. Pryzwanski, Applications of double-label imunofluorescence. Techniques in immunochemistry, pp.83-89, 1982.

. Hopf-u, B. K. Meyer-zum, and J. Freundenberg, Loca li sation of a membrane antigen at cell surface of iso l ate d hepatocytes, Clin. Exp. Immuno1, vol.16, pp.117-123, 1974.

H. Satoh, H. W. Davies, T. Takemura, . R. Gillett-e-j, K. Maeda et al., , 1987.

, An immunochemical approach to investigating the mechanis rn of halothane-induced hepatotoxic ity, p.6

P. Stasiecki and . Oesch-f, Distributi on of en zymes involvedrn metabolism of polycyc lic a r oma tic hydrocarb ons among rat liver endomembranes and plasma membranes, 1980.

, Eur. J. Cell. Biol, pp.79-92

A. M. Siest-g, . Fournels, . Visvi, W. Ki-s-a, and . Ellman--·-bednawska-m, Subce llular localisation of drug metabolizing enzymes ln re l atio n to their functio n. Drug Metabo li smfrommo1 ecules to man, p.0, 1987.

. Oesch-f, . Be, . Le-y-p, M. Golan, and . Stas-ie-cki-p, Metabolism of ben zo(a)pyrene by subcellu1ar fractions of rat live r : evidence fo r similar patterns of cytochrome P-450 in rough and smooth endoplasmi c reticulum but not in nuclei and pla sma membrane, Cancer Res, vol.45, pp.4838-4842, 1985.

C. Amar, . M. Dansette-p, J. P. Girault, and . Mansuy-d,

P. Lazarow and D. C. De, A fatty acyl-CoA oxydizing system in rat liver perox i some s enhan cement by clo fib r ate, a hypo l ip idemic drug, Proc . Nat l . Acad. Sei, vol.73, pp.20-43, 1976.

. Yamamoto-a, . Masaki-r, and Y. Tashiro, Is cytochrome P-450 transported from the endoplasmic reticulum to the Golgi apparatus in rat hepatocytes ?, J. Ce11 Biol, vol.101, pp.1733-1740, 1985.

L. De, . B. Frey-a, . D. Sabatini-d, . Kre-i-bi, and . Ch-g, 8 7) Determination of the membrane topology of the PB-inducible rat liver cytochrome P-450 isoenzyme PB-4 using sitespecifie antibodies, vol.19

, J. Cell Biol, vol.104, pp.209-219

C. Brown and . Black-s, Membrane topology of mammalian cytochromes P-450 from liver endoplasmic reticulum, 1989.

, J. Biol. Chem, vol.264, pp.4442-4449

Z. Immer.t\1an and H. J. Shak-k, 8 7) The hepa tic injury of MAO inhibitors, vol.19

, J. Clin. Psychopharmacol, vol.2, pp.211-213

G. Danan, J. C. Homberg, J. Bernuau, J. Roche-sicot, and . Pessayre-d, , 1983.

, Hépatite à l'iproniazide. Intérêt diagnostique d'un nouvel anticorps anti-mitochondrial, l'anti-M6

, Gastroenterol. Clin. biol, vol.2, pp.529-532

. E. Smith-t, H. Weissbach, and . Undenfriend-s, Studies on MAO : the mechanism of inhibition of MAO by iproniazid, Biochemistry, vol.2, pp.746-751, 1963.

. W. Bach-a, . C. Lan-n, . L. Johnson-d, C. W. Abell, . E. Bembenek-m et al., ) eDNA cloning of human liver MAO A and B molecular basis of differences in enzymatic properties. Pr oc . Na tl, 1988.

. F. Tipton-k, 1980) l'<lonoarnine oxydase . Enzyrnatic basis of detoxication, vol.1, pp.355-370

. Glover-v and . Sandler-m, Clinica l Chemistry of MAO, Cell Biochemistry and function, vol.4, pp.89-97, 1986.

. P. Singer-t, Mitochondrial rnonoarnine oxydase, 1985.

C. S. and W. Eyler-w, Partia l arnino acid sequence anal ysis of hurnan placenta MAO A and bovine liver MAO B, Biochern . Biophys . Res~ Corn, vol.156, pp.445-450, 1988.

N. S. Mitchell, J. Snodgrass-w, and J. Timbrell, Hepatotoxicity and metabolisrn of iproniazid and isopropylhydr azine, 1978.

, J. Pharmaco1. Exp . Ther, vol.206, pp.1-574

N. Gomel, M. Unzeta, . Tipton-k, . Anderson-m, and . M. O&apos;carroll-a, Determ ination of MAO concentrations in rat liver by inhibitor binding, 1986.

, Biochern . Pharrnaco1., ~', vol.24, pp.4467-4472

. Gomez-n, D. Balsa, and . Unzeta-m, A comparative study of sorne kinet i c and rnol ecular properties of rnicrosorna1 and rnitochondrial MAO, Biochem . Pharrnaco1., ~', vol.18, pp.3407-3413, 1988.

. Stroli-n-bene-detti-m, P. Dostert, and . Tipton-k, Contribu t ions of MAO to the rnetabolisrn of xenobiotics. Progress in drug rnetabolis~, vol.15, pp.0-1, 1989.

. G. Dennick-r and J. Mayer, 77) Purification and immunochemica l charact er iz a~ion of MAO fr om rat and human liver, Bio che rn . J, vol.16, issue.1

. Billette, . Gunn-b, and J. Mayer, 984) Characterization of two monoclonal antibodies obtaine d after immunizat ion with human liver mitochondrial memb rane preparations, Biochem. J, vol.221, pp.765-776

R. S. and D. J. Mayer-r, The vectorial orient a tion of human MAO in the mitochondrial outer membrane . Bi ochem, J, vol.181, pp.7-14, 1979.

R. S. Mayer-r, Degradat ion of transplanted rat liver mitochondrial ou ter membrane proteins in hepatoma cells, Biochem. J, vol.216, pp.163-175, 1983.

J. L. Lety, M. A. Bach, and J. F. Louvard-d, Human system i c lupus erythemat osus sera cont a in an t i bod ies aga inst cell-s ur face proteins that share epitope with DNA, Proc. Natl. Acad. Sei. USA, pp.6970-6974, 1986.

. S. Fujinami-r and M. B. Oldstone, Molecular mimicry as a mechanism f or virus -induced autoimmunity, Immunol. Res, pp.3-15, 1989.

J. P. Uetrecht, Mec hanism of drug-induced lupus, Chem. Res. Toxicol., ~', vol.3, pp.133-143, 1988.

J. F. Bach, 7) Les mécanismes de l' au toimmunité

, C.R . Soc. Bio l, vol.181, pp.5-10