, En fait, l'acide tiénilique et l' i pronia zide condui sent à l' appa rition d'anticorps anti -tissus très spécifiques , n on rencontrés dans d'autres types d'hépatites. Cela renforce l'idée que le cytochrome P-450-8 . . . et la MAO B sont non seulemen t reconnus par l es anticorps anti-LKMZ ou anti-M6 mais seraient éga lement les antigènes responsables de l' appar ition des ces anticorps in v i vo
, il a é t é récemment étab li que l es anticorps anti -LKMl, dé t ectés dans l e sérum de ces patient s , r econnai ssent un cytochrome P-450 de foie humain, l e cy tochrome P-450-buf I ou II (77) ou dbl (78) de la sous -famille IID. Toutefois, dans ces hépatite s, Le problème s'avère plu s comple x~ dans le cas d'autres hépatites de type immune-allergique. Ainsi , dans les hépatites chroniques ac ti ves (CAH)
, les anticorp s anti-ADN détectés dans le sér um de ces ma l ades réa gissent non seu l ement avec l'ADN mai s au ss i avec des phospholipides et une protéine membranaire (109), Dan s l e cas du lupus éryth émateux diss éminé (SLE )
, Il a éga l ement é t é propo sé que des v1rus soient la cau se de certain es réac tions auto-immunes, s oit par l'expression d' an ti gè nes vir aux à l a su rfa ce de cellules i nfectées, soit par le biai s d ' auto -anticorps anti -virus dont les id i ot ype s peuvent donner li eu à des réactions croi sées avec certains
, Une autre hypothèse pour l' appa rition d'auto-anticorp s s circulantes (monocy t es , neutrophi l es). L'inte r action du médicament et d e ces cel lul es conduit à l a présentation d 'un néo -antigène par ces cel lul es , pui s à la production d ' antico rp s par l
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