Cytoprotective activated protein C averts Nlrp3 inflammasome–induced ischemia-reperfusion injury via mTORC1 inhibition - Archive ouverte HAL Access content directly
Journal Articles Blood Year : 2017

Cytoprotective activated protein C averts Nlrp3 inflammasome–induced ischemia-reperfusion injury via mTORC1 inhibition

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Sumra Nazir
  • Function : Author
Ihsan Gadi
  • Function : Author
Moh’d Mohanad Al-Dabet
  • Function : Author
Ahmed Elwakiel
  • Function : Author
Shrey Kohli
  • Function : Author
Sanchita Ghosh
  • Function : Author
Jayakumar Manoharan
  • Function : Author
Satish Ranjan
  • Function : Author
Fabian Bock
  • Function : Author
Ruediger Braun-Dullaeus
  • Function : Author
Charles Esmon
  • Function : Author
Tobias Huber
  • Function : Author
Eric Camerer
Chris Dockendorff
  • Function : Author
John Griffin
  • Function : Author
Berend Isermann
  • Function : Author
Khurrum Shahzad
  • Function : Author

Abstract

Key Points aPC protects from myocardial and renal IRIs by restricting mTORC1-mediated activation of the Nlrp3 inflammasome. Nlrp3 inflammasome suppression by aPC is independent of its anticoagulant effect, depends on PAR-1, and can be mimicked by parmodulin-2.

Dates and versions

hal-03906075 , version 1 (19-12-2022)

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Cite

Sumra Nazir, Ihsan Gadi, Moh’d Mohanad Al-Dabet, Ahmed Elwakiel, Shrey Kohli, et al.. Cytoprotective activated protein C averts Nlrp3 inflammasome–induced ischemia-reperfusion injury via mTORC1 inhibition. Blood, 2017, 130 (24), pp.2664-2677. ⟨10.1182/blood-2017-05-782102⟩. ⟨hal-03906075⟩
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