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Les basophiles : de l’allergie aux maladies auto-immunes

Abstract : Autoimmune diseases originate from a break in the tolerance to some self-antigens. Autoantibody (AAb) production can be initiated in such settings that may have a pathogenic function. These AAb are often associated to specific organ damages occurring in the course of these diseases. AAb production promotion by some elements from acquired and innate immune systems will be central in the development of organ damages. These AAb can have various specificities and isotypes. Autoreactive IgE have been described in several antibody-associated autoimmune diseases (AAID) and can have a pathogenic role at different levels. Basophils, cells well known for their implication in allergies and antiparasitic immunity, can be activated by autoreactive IgE and contribute to the amplification of AAb production in several AAID. Here, the recent data showing basophil, IgE and autoreactive IgE involvements in AAID, and more precisely in systemic lupus erythematosus and mixed connective tissue disease, in human patients and mouse models, will be presented. Therapeutic strategies developed in this context in AAID will be also discussed.
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Submitted on : Thursday, June 9, 2022 - 11:23:31 AM
Last modification on : Saturday, June 25, 2022 - 3:44:04 AM

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N. Charles. Les basophiles : de l’allergie aux maladies auto-immunes. Revue francaise d'allergologie, Elsevier, 2022, 62 (3), pp.211-213. ⟨10.1016/j.reval.2022.02.217⟩. ⟨hal-03691642⟩

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