Design and synthesis of a peptide derivative of ametantrone targeting the major groove of the d(GGCGCC) 2 palindromic sequence - Archive ouverte HAL Access content directly
Journal Articles New Journal of Chemistry Year : 2020

Design and synthesis of a peptide derivative of ametantrone targeting the major groove of the d(GGCGCC) 2 palindromic sequence

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Abstract

We report the synthesis of a peptide derivative of antitumor anthraquinones, designed to target GC-rich palindromic sequences. It has micromolar activities on three cancer cell lines and is fifty times less toxic than mitoxantrone on a healthy line.
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Dates and versions

hal-03689989 , version 1 (07-06-2022)

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Alberto Ongaro, Giovanni Ribaudo, Emmanuelle Braud, Mélanie Ethève-Quelquejeu, Michele de Franco, et al.. Design and synthesis of a peptide derivative of ametantrone targeting the major groove of the d(GGCGCC) 2 palindromic sequence. New Journal of Chemistry, 2020, 44 (9), pp.3624-3631. ⟨10.1039/C9NJ03817E⟩. ⟨hal-03689989⟩
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