Design and synthesis of a peptide derivative of ametantrone targeting the major groove of the d(GGCGCC) 2 palindromic sequence

Alberto Ongaro; Giovanni Ribaudo; Emmanuelle Braud; Mélanie Ethève-Quelquejeu; Michele de Franco; Christiane Garbay; Luc Demange; Nohad Gresh; Giuseppe Zagotto

doi:10.1039/C9NJ03817E

Journal articles

Design and synthesis of a peptide derivative of ametantrone targeting the major groove of the d(GGCGCC) 2 palindromic sequence

Alberto Ongaro ¹ Giovanni Ribaudo ¹ Emmanuelle Braud ² Mélanie Ethève-Quelquejeu Michele de Franco Christiane Garbay ² Luc Demange ³ Nohad Gresh ⁴ Giuseppe Zagotto ⁵

1 Università degli Studi di Brescia [Brescia]

2 LCBPT - UMR 8601 - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques

3 ICN - Institut de Chimie de Nice

4 LCT - Laboratoire de chimie théorique

5 Department of Pharmaceutical and Pharmacological Sciences [Padova]

Abstract : We report the synthesis of a peptide derivative of antitumor anthraquinones, designed to target GC-rich palindromic sequences. It has micromolar activities on three cancer cell lines and is fifty times less toxic than mitoxantrone on a healthy line.

Document type :

Journal articles

Domain :

Chemical Sciences

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https://hal-univ-paris.archives-ouvertes.fr/hal-03689989
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Submitted on : Tuesday, June 7, 2022 - 5:18:51 PM
Last modification on : Thursday, June 9, 2022 - 3:11:53 AM

Design and synthesis of a peptide derivative of ametantrone targeting the major groove of the d(GGCGCC) 2 palindromic sequence

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Design and synthesis of a peptide derivative of ametantrone targeting the major groove of the d(GGCGCC) 2 palindromic sequence

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