Design and synthesis of a peptide derivative of ametantrone targeting the major groove of the d(GGCGCC) 2 palindromic sequence - Université Paris Cité Accéder directement au contenu
Article Dans Une Revue New Journal of Chemistry Année : 2020

Design and synthesis of a peptide derivative of ametantrone targeting the major groove of the d(GGCGCC) 2 palindromic sequence

Résumé

We report the synthesis of a peptide derivative of antitumor anthraquinones, designed to target GC-rich palindromic sequences. It has micromolar activities on three cancer cell lines and is fifty times less toxic than mitoxantrone on a healthy line.

Domaines

Chimie
Fichier non déposé

Dates et versions

hal-03689989 , version 1 (07-06-2022)

Identifiants

Citer

Alberto Ongaro, Giovanni Ribaudo, Emmanuelle Braud, Mélanie Ethève-Quelquejeu, Michele de Franco, et al.. Design and synthesis of a peptide derivative of ametantrone targeting the major groove of the d(GGCGCC) 2 palindromic sequence. New Journal of Chemistry, 2020, 44 (9), pp.3624-3631. ⟨10.1039/C9NJ03817E⟩. ⟨hal-03689989⟩
6 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More