Metabolic Oxidative Cleavage of Thioesters: Evidence for the Formation of Sulfenic Acid Intermediates in the Bioactivation of the Antithrombotic Prodrugs Ticlopidine and Clopidogrel

Patrick Dansette; Julie Libraire; Gildas Bertho; Daniel Mansuy

doi:10.1021/tx8004828

Journal articles

Metabolic Oxidative Cleavage of Thioesters: Evidence for the Formation of Sulfenic Acid Intermediates in the Bioactivation of the Antithrombotic Prodrugs Ticlopidine and Clopidogrel

Patrick Dansette ^{1, 2} Julie Libraire Gildas Bertho ¹ Daniel Mansuy

1 UPD5 - Université Paris Descartes - Paris 5

2 LCBPT - UMR 8601 - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques

Document type :

Journal articles

Domain :

Chemical Sciences

Life Sciences [q-bio]

Complete list of metadata

https://hal-univ-paris.archives-ouvertes.fr/hal-03684993
Contributor : Gildas BERTHO Connect in order to contact the contributor
Submitted on : Wednesday, June 1, 2022 - 5:34:18 PM
Last modification on : Saturday, June 25, 2022 - 3:43:29 AM

Metabolic Oxidative Cleavage of Thioesters: Evidence for the Formation of Sulfenic Acid Intermediates in the Bioactivation of the Antithrombotic Prodrugs Ticlopidine and Clopidogrel

Identifiers

Collections

Citation

Export

Metrics

8

Metabolic Oxidative Cleavage of Thioesters: Evidence for the Formation of Sulfenic Acid Intermediates in the Bioactivation of the Antithrombotic Prodrugs Ticlopidine and Clopidogrel

Identifiers

Collections

Citation

Export

Share

Metrics

8