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Metabolic Oxidative Cleavage of Thioesters: Evidence for the Formation of Sulfenic Acid Intermediates in the Bioactivation of the Antithrombotic Prodrugs Ticlopidine and Clopidogrel

Patrick Dansette 1, 2 Julie Libraire Gildas Bertho 1 Daniel Mansuy 
1 UPD5 - Université Paris Descartes - Paris 5
2 LCBPT - UMR 8601 - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques
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https://hal-univ-paris.archives-ouvertes.fr/hal-03684993
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Submitted on : Wednesday, June 1, 2022 - 5:34:18 PM
Last modification on : Saturday, June 25, 2022 - 3:43:29 AM

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Patrick Dansette, Julie Libraire, Gildas Bertho, Daniel Mansuy. Metabolic Oxidative Cleavage of Thioesters: Evidence for the Formation of Sulfenic Acid Intermediates in the Bioactivation of the Antithrombotic Prodrugs Ticlopidine and Clopidogrel. Chemical Research in Toxicology, American Chemical Society, 2009, 22 (2), pp.369-373. ⟨10.1021/tx8004828⟩. ⟨hal-03684993⟩

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