Metabolic Activation of Prasugrel: Nature of the Two Competitive Pathways Resulting in the Opening of Its Thiophene Ring

Patrick Dansette (1, 2) , Julien Rosi (1, 2) , Justine Debernardi (1, 2) , Gildas Bertho (1, 2) , Daniel Mansuy (1, 2)

1 UPD5 - Université Paris Descartes - Paris 5
2 LCBPT - UMR 8601 - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques

Domains: Life Sciences [q-bio]

Patrick Dansette, Julien Rosi, Justine Debernardi, Gildas Bertho, Daniel Mansuy. Metabolic Activation of Prasugrel: Nature of the Two Competitive Pathways Resulting in the Opening of Its Thiophene Ring. Chemical Research in Toxicology, 2012, 25 (5), pp.1058-1065. ⟨10.1021/tx3000279⟩. ⟨hal-03684932⟩