Thiolactone Sulfoxides as New Reactive Metabolites Acting as Bis-Electrophiles: Implication in Clopidogrel and Prasugrel Bioactivation

Patrick Dansette (1, 2) , Dan Levent , Assia Hessani , Gildas Bertho (1, 2) , Daniel Mansuy (1, 2)

1 UPD5 - Université Paris Descartes - Paris 5
2 LCBPT - UMR 8601 - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques

Domains: Chemical Sciences; Chemical Sciences; Analytical chemistry

Patrick Dansette, Dan Levent, Assia Hessani, Gildas Bertho, Daniel Mansuy. Thiolactone Sulfoxides as New Reactive Metabolites Acting as Bis-Electrophiles: Implication in Clopidogrel and Prasugrel Bioactivation. Chemical Research in Toxicology, 2013, 26 (5), pp.794-802. ⟨10.1021/tx400083b⟩. ⟨hal-03684856⟩