Thiolactone Sulfoxides as New Reactive Metabolites Acting as Bis-Electrophiles: Implication in Clopidogrel and Prasugrel Bioactivation

Patrick Dansette; Dan Levent; Assia Hessani; Gildas Bertho; Daniel Mansuy

doi:10.1021/tx400083b

Journal articles

Thiolactone Sulfoxides as New Reactive Metabolites Acting as Bis-Electrophiles: Implication in Clopidogrel and Prasugrel Bioactivation

Patrick Dansette ^{1, 2} Dan Levent Assia Hessani Gildas Bertho ^{1, 2} Daniel Mansuy ^{1, 2}

1 UPD5 - Université Paris Descartes - Paris 5

2 LCBPT - UMR 8601 - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques

Document type :

Journal articles

Domain :

Chemical Sciences

Chemical Sciences / Analytical chemistry

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https://hal-univ-paris.archives-ouvertes.fr/hal-03684856
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Submitted on : Wednesday, June 1, 2022 - 4:36:10 PM
Last modification on : Saturday, June 25, 2022 - 3:43:29 AM

Thiolactone Sulfoxides as New Reactive Metabolites Acting as Bis-Electrophiles: Implication in Clopidogrel and Prasugrel Bioactivation

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Thiolactone Sulfoxides as New Reactive Metabolites Acting as Bis-Electrophiles: Implication in Clopidogrel and Prasugrel Bioactivation

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