A hierarchical transcriptional network activates specific CDK inhibitors that regulate G2 to control cell size and number in Arabidopsis - Archive ouverte HAL Access content directly
Journal Articles Nature Communications Year : 2022

A hierarchical transcriptional network activates specific CDK inhibitors that regulate G2 to control cell size and number in Arabidopsis

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Yuji Nomoto
  • Function : Author
Takamasa Suzuki
Kenichiro Maeo
  • Function : Author
Miyu Imamura
  • Function : Author
Keiko Sugimoto
Masaki Ito
  • Function : Correspondent author
  • PersonId : 1142059

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Abstract

Abstract How cell size and number are determined during organ development remains a fundamental question in cell biology. Here, we identified a GRAS family transcription factor, called SCARECROW-LIKE28 (SCL28), with a critical role in determining cell size in Arabidopsis. SCL28 is part of a transcriptional regulatory network downstream of the central MYB3Rs that regulate G2 to M phase cell cycle transition. We show that SCL28 forms a dimer with the AP2-type transcription factor, AtSMOS1, which defines the specificity for promoter binding and directly activates transcription of a specific set of SIAMESE-RELATED (SMR) family genes, encoding plant-specific inhibitors of cyclin-dependent kinases and thus inhibiting cell cycle progression at G2 and promoting the onset of endoreplication. Through this dose-dependent regulation of SMR transcription, SCL28 quantitatively sets the balance between cell size and number without dramatically changing final organ size. We propose that this hierarchical transcriptional network constitutes a cell cycle regulatory mechanism that allows to adjust cell size and number to attain robust organ growth.
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Dates and versions

hal-03666165 , version 1 (12-05-2022)

Licence

Attribution - CC BY 4.0

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Yuji Nomoto, Hirotomo Takatsuka, Kesuke Yamada, Toshiya Suzuki, Takamasa Suzuki, et al.. A hierarchical transcriptional network activates specific CDK inhibitors that regulate G2 to control cell size and number in Arabidopsis. Nature Communications, 2022, 13 (1), pp.1-16. ⟨10.1038/s41467-022-29316-2⟩. ⟨hal-03666165⟩
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