Skip to Main content Skip to Navigation
Journal articles

Overexpression of Nucleolin and Associated Genes in Prostate Cancer

Abstract : Prostate cancer (PCa) is the second most frequent cancer and the fifth leading cause of cancer death in men worldwide. If local PCa presents a favorable prognosis, available treatments for advanced PCa display limiting benefits due to therapeutic resistances. Nucleolin (NCL) is a ubiquitous protein involved in numerous cell processes, such as ribosome biogenesis, cell cycles, or angiogenesis. NCL is overexpressed in several tumor types in which it has been proposed as a diagnostic and prognostic biomarker. In PCa, NCL has mainly been studied as a target for new therapeutic agents. Nevertheless, little data are available concerning its expression in patient tissues. Here, we investigated the expression of NCL using a new cohort from Mondor Hospital and data from published cohorts. Results were then compared with NCL expression using in vitro models. NCL was overexpressed in PCa tissues compared to the normal tissues, but no prognostic values were demonstrated. Nine genes were highly co-expressed with NCL in patient tissues and tumor prostate cell lines. Our data demonstrate that NCL is an interesting diagnostic biomarker and propose a signature of genes co-expressed with NCL.
Complete list of metadata
Contributor : Equipe HAL Université Paris Cité Connect in order to contact the contributor
Submitted on : Tuesday, May 10, 2022 - 2:50:41 PM
Last modification on : Thursday, September 22, 2022 - 7:38:20 AM


Firlej_Soyeux_Nourieh et al......
Publisher files allowed on an open archive


Distributed under a Creative Commons Attribution 4.0 International License



Virginie Firlej, Pascale Soyeux, Maya Nourieh, Eric Huet, Fannie Semprez, et al.. Overexpression of Nucleolin and Associated Genes in Prostate Cancer. International Journal of Molecular Sciences, MDPI, 2022, 23 (9), pp.4491. ⟨10.3390/ijms23094491⟩. ⟨hal-03663714⟩



Record views


Files downloads