Skip to Main content Skip to Navigation
Journal articles

Genome-Wide Association Study of Fluorescent Oxidation Products Accounting for Tobacco Smoking Status in Adults from the French EGEA Study

Abstract : Oxidative stress (OS) is the main pathophysiological mechanism involved in several chronic diseases, including asthma. Fluorescent oxidation products (FlOPs), a global biomarker of damage due to OS, is of growing interest in epidemiological studies. We conducted a genome-wide association study (GWAS) of the FlOPs level in 1216 adults from the case-control and family-based EGEA study (mean age 43 years old, 51% women, and 23% current smokers) to identify genetic variants associated with FlOPs. The GWAS was first conducted in the whole sample and then stratified according to smoking status, the main exogenous source of reactive oxygen species. Among the top genetic variants identified by the three GWAS, those located in BMP6 (p = 3 × 10−6), near BMPER (p = 9 × 10−6), in GABRG3 (p = 4 × 10−7), and near ATG5 (p = 2 × 10−9) are the most relevant because of both their link to biological pathways related to OS and their association with several chronic diseases for which the role of OS in their pathophysiology has been pointed out. BMP6 and BMPER are of particular interest due to their involvement in the same biological pathways related to OS and their functional interaction. To conclude, this study, which is the first GWAS of FlOPs, provides new insights into the pathophysiology of chronic OS-related diseases.
Complete list of metadata

https://hal-univ-paris.archives-ouvertes.fr/hal-03663635
Contributor : Equipe HAL Université Paris Cité Connect in order to contact the contributor
Submitted on : Tuesday, May 10, 2022 - 12:15:13 PM
Last modification on : Friday, August 5, 2022 - 11:57:54 AM

File

Orsi_Margaritte-Jeannin_Andria...
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Laurent Orsi, Patricia Margaritte-Jeannin, Miora Andrianjafimasy, Orianne Dumas, Hamida Mohamdi, et al.. Genome-Wide Association Study of Fluorescent Oxidation Products Accounting for Tobacco Smoking Status in Adults from the French EGEA Study. Antioxidants , MDPI, 2022, 11 (5), pp.802. ⟨10.3390/antiox11050802⟩. ⟨hal-03663635⟩

Share

Metrics

Record views

40

Files downloads

16