Neurocognitive modeling of latent memory processes reveals reorganization of hippocampal-cortical circuits underlying learning and efficient strategies

Kaustubh Supekar (1) , Hyesang Chang (1) , Percy K Mistry (1) , Teresa Iuculano (2) , Vinod Menon (1)

1 Department of Psychiatry and Behavioral Sciences [Stanford]
2 LaPsyDÉ - UMR 8240 - Laboratoire de psychologie du développement et de l'éducation de l'enfant

Abstract Efficient memory-based problem-solving strategies are a cardinal feature of expertise across a wide range of cognitive domains in childhood. However, little is known about the neurocognitive mechanisms that underlie the acquisition of efficient memory-based problem-solving strategies. Here we develop, to the best of our knowledge, a novel neurocognitive process model of latent memory processes to investigate how cognitive training designed to improve children’s problem-solving skills alters brain network organization and leads to increased use and efficiency of memory retrieval-based strategies. We found that training increased both the use and efficiency of memory retrieval. Functional brain network analysis revealed training-induced changes in modular network organization, characterized by increase in network modules and reorganization of hippocampal-cortical circuits. Critically, training-related changes in modular network organization predicted performance gains, with emergent hippocampal, rather than parietal cortex, circuitry driving gains in efficiency of memory retrieval. Our findings elucidate a neurocognitive process model of brain network mechanisms that drive learning and gains in children’s efficient problem-solving strategies.

Domaines: Sciences du Vivant [q-bio]

Kaustubh Supekar, Hyesang Chang, Percy K Mistry, Teresa Iuculano, Vinod Menon. Neurocognitive modeling of latent memory processes reveals reorganization of hippocampal-cortical circuits underlying learning and efficient strategies. Communications Biology, 2021, 4 (1), ⟨10.1038/s42003-021-01872-1⟩. ⟨hal-03258351⟩