Identifying sex-specific differences in the carotid revascularisation literature: findings from a scoping review - Archive ouverte HAL Access content directly
Journal Articles Stroke and Vascular Neurology Year : 2021

Identifying sex-specific differences in the carotid revascularisation literature: findings from a scoping review

(1) , , , , , , , , (2, 3) , , , (4)
1
2
3
4
Michel Shamy
  • Function : Author
  • PersonId : 1101896
Brian Dewar
  • Function : Author
Dean A Fergusson
  • Function : Author
Dar Dowlatshahi
  • Function : Author
Candyce Hamel
  • Function : Author
Sophia Gocan
  • Function : Author
Mark Fedyk
  • Function : Author
Peter Rothwell
  • Function : Author
Virginia Howard
  • Function : Author

Abstract

Objective No systematic review of the literature has dedicated itself to looking at the management of symptomatic carotid stenosis in female patients. In this scoping review, we aimed to identify all randomised controlled trials (RCTs) that reported sex-specific outcomes for patients who underwent carotid revascularisation, and determine whether sufficient information is reported within these studies to assess short-term and long-term outcomes in female patients. Design, setting and participants We systematically searched Medline, Embase, Pubmed and Cochrane libraries for RCTs published between 1991 and 2020 that included female patients and compared either endarterectomy with stenting, or any revascularisation (endarterectomy or stenting) with medical therapy in patients with symptomatic high-grade (>50%) carotid stenosis. Results From 1537 references examined, 27 eligible studies were identified. Sex-specific outcomes were reported in 13 studies. Baseline patient characteristics of enrolled female patients were reported in 2 of those 13 studies. Common outcomes reported included stroke and death, however, there was significant heterogeneity in the reporting of both periprocedural and long-term outcomes. Sex-specific differences relating to the degree of stenosis and time from index event to treatment are largely limited to studies comparing endarterectomy to medical therapy. Adverse events were not reported by sex. Conclusions Only half of the previously published RCTs and systematic reviews report sex-specific outcomes. Detailed analyses on the results of carotid artery intervention for female patients with symptomatic stenosis are limited.
Fichier principal
Vignette du fichier
svn-2020-000744.full.pdf (660.61 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

hal-03258302 , version 1 (11-06-2021)

Licence

Attribution - NonCommercial - CC BY 4.0

Identifiers

Cite

Vignan Yogendrakumar, Michel Shamy, Brian Dewar, Dean A Fergusson, Dar Dowlatshahi, et al.. Identifying sex-specific differences in the carotid revascularisation literature: findings from a scoping review. Stroke and Vascular Neurology, 2021, pp.svn-2020-000744. ⟨10.1136/svn-2020-000744⟩. ⟨hal-03258302⟩

Collections

UNIV-PARIS
8 View
24 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More