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Journal Articles Cell Reports Year : 2021

Dietary spermidine improves cognitive function

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Sabrina Schroeder
  • Function : Author
Sebastian J Hofer
Andreas Zimmermann
Raimund Pechlaner
  • Function : Author
Christopher Dammbrueck
  • Function : Author
Tobias Pendl
  • Function : Author
G. Mark Mark Marcello
  • Function : Author
Viktoria Pogatschnigg
  • Function : Author
Martina Bergmann
  • Function : Author
Melanie Müller
  • Function : Author
Verena Gschiel
  • Function : Author
Selena Ristic
  • Function : Author
Jelena Tadic
  • Function : Author
Keiko Iwata
  • Function : Author
Gesa Richter
  • Function : Author
Aitak Farzi
  • Function : Author
Muammer Üçal
  • Function : Author
Ute Schäfer
  • Function : Author
Michael Poglitsch
  • Function : Author
Philipp Royer
  • Function : Author
Ronald Mekis
  • Function : Author
Marlene Agreiter
  • Function : Author
Regine C Tölle
  • Function : Author
Péter Sótonyi
  • Function : Author
Johann Willeit
  • Function : Author
Barbara Mairhofer
  • Function : Author
Helga Niederkofler
  • Function : Author
Irmgard Pallhuber
  • Function : Author
Gregorio Rungger
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Herbert Tilg
Michaela Defrancesco
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Josef Marksteiner
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Frank Sinner
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Christoph Magnes
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Thomas R Pieber
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Peter Holzer
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Didac Carmona-Gutierrez
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Luca Scorrano
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Jörn Dengjel
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Tobias Madl
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Simon Sedej
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Stephan J Sigrist
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Bence Rácz
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Stefan Kiechl
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  • PersonId : 1100882
Tobias Eisenberg
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  • PersonId : 1100883
Frank Madeo
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  • PersonId : 1069889

Abstract

Decreased cognitive performance is a hallmark of brain aging, but the underlying mechanisms and potential therapeutic avenues remain poorly understood. Recent studies have revealed health-protective and lifespan-extending effects of dietary spermidine, a natural autophagy-promoting polyamine. Here, we show that dietary spermidine passes the blood-brain barrier in mice and increases hippocampal eIF5A hypusination and mitochondrial function. Spermidine feeding in aged mice affects behavior in homecage environment tasks, improves spatial learning, and increases hippocampal respiratory competence. In a Drosophila aging model, spermidine boosts mitochondrial respiratory capacity, an effect that requires the autophagy regulator Atg7 and the mitophagy mediators Parkin and Pink1. Neuron-specific Pink1 knockdown abolishes spermidine-induced improvement of olfactory associative learning. This suggests that the maintenance of mitochondrial and autophagic function is essential for enhanced cognition by spermidine feeding. Finally, we show large-scale prospective data linking higher dietary spermidine intake with a reduced risk for cognitive impairment in humans
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Dates and versions

hal-03247734 , version 1 (03-06-2021)

Licence

Attribution - CC BY 4.0

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Sabrina Schroeder, Sebastian J Hofer, Andreas Zimmermann, Raimund Pechlaner, Christopher Dammbrueck, et al.. Dietary spermidine improves cognitive function. Cell Reports, 2021, 35 (2), pp.108985. ⟨10.1016/j.celrep.2021.108985⟩. ⟨hal-03247734⟩
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