Skip to Main content Skip to Navigation
Journal articles

Viral infections in humans and mice with genetic deficiencies of the type I IFN response pathway

Abstract : Type I IFNs are so-named because they interfere with viral infection in vertebrate cells. The study of cellular responses to type I IFNs led to the discovery of the JAK-STAT signaling pathway, which also governs the response to other cytokine families. We review here the outcome of viral infections in mice and humans with engineered and inborn deficiencies, respectively, of (i) IFNAR1 or IFNAR2, selectively disrupting responses to type I IFNs, (ii) STAT1, STAT2, and IRF9, also impairing cellular responses to type II (for STAT1) and/or III (for STAT1, STAT2, IRF9) IFNs, and (iii) JAK1 and TYK2, also impairing cellular responses to cytokines other than IFNs. A picture is emerging of greater redundancy of human type I IFNs for protective immunity to viruses in natural conditions than was initially anticipated. Mouse type I IFNs are essential for protection against a broad range of viruses in experimental conditions. These findings suggest that various type I IFN-independent mechanisms of human cell-intrinsic immunity to viruses have yet to be discovered.
Document type :
Journal articles
Complete list of metadata

https://hal-univ-paris.archives-ouvertes.fr/hal-03246535
Contributor : Equipe Hal Paris Diderot <>
Submitted on : Wednesday, June 2, 2021 - 2:04:38 PM
Last modification on : Wednesday, July 21, 2021 - 4:10:02 PM

Links full text

Identifiers

Collections

Citation

Isabelle Meyts, Jean‐laurent Casanova. Viral infections in humans and mice with genetic deficiencies of the type I IFN response pathway. European Journal of Immunology, Wiley-VCH Verlag, 2021, 51 (5), pp.1039-1061. ⟨10.1002/eji.202048793⟩. ⟨hal-03246535⟩

Share

Metrics

Record views

32