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The EU Child Cohort Network’s core data: establishing a set of findable, accessible, interoperable and re-usable (FAIR) variables

Angela Pinot de Moira 1, * Sido Haakma 2 Katrine Strandberg-Larsen 1 Esther van Enckevort 2 Marjolein Kooijman 3 Tim Cadman 4 Marloes Cardol 2 Eva Corpeleijn 2 Sarah Crozier 5 Liesbeth Duijts 3 Ahmed Elhakeem 4 Johan Eriksson 6, 7, 8 Janine Felix 3 Sílvia Fernández-Barrés 9, 10 Rachel Foong 11 Anne Forhan 12 Veit Grote Kathrin Guerlich Barbara Heude 12 Rae-Chi Huang Marjo-Riitta Järvelin 13, 14 Anne Cathrine Jørgensen 1 Tuija Mikkola 8, 6 Johanna Nader 15 Marie Pedersen 1 Maja Popovic 16 Nina Rautio 13 Lorenzo Richiardi 16 Justiina Ronkainen 13 Theano Roumeliotaki 17 Theodosia Salika 5 Sylvain Sebert 13 Johan Vinther 1 Ellis Voerman 3 Martine Vrijheid 9, 10 John Wright Tiffany Yang Faryal Zariouh 12 Marie-Aline Charles 12, 18 Hazel Inskip 5 Vincent Jaddoe 3 Morris Swertz 3 Anne-Marie Nybo Andersen 1 
Abstract : Abstract The Horizon2020 LifeCycle Project is a cross-cohort collaboration which brings together data from multiple birth cohorts from across Europe and Australia to facilitate studies on the influence of early-life exposures on later health outcomes. A major product of this collaboration has been the establishment of a FAIR (findable, accessible, interoperable and reusable) data resource known as the EU Child Cohort Network. Here we focus on the EU Child Cohort Network’s core variables. These are a set of basic variables, derivable by the majority of participating cohorts and frequently used as covariates or exposures in lifecourse research. First, we describe the process by which the list of core variables was established. Second, we explain the protocol according to which these variables were harmonised in order to make them interoperable. Third, we describe the catalogue developed to ensure that the network’s data are findable and reusable. Finally, we describe the core data, including the proportion of variables harmonised by each cohort and the number of children for whom harmonised core data are available. EU Child Cohort Network data will be analysed using a federated analysis platform, removing the need to physically transfer data and thus making the data more accessible to researchers. The network will add value to participating cohorts by increasing statistical power and exposure heterogeneity, as well as facilitating cross-cohort comparisons, cross-validation and replication. Our aim is to motivate other cohorts to join the network and encourage the use of the EU Child Cohort Network by the wider research community.
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Submitted on : Saturday, May 29, 2021 - 12:08:09 PM
Last modification on : Wednesday, September 28, 2022 - 5:55:49 AM

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Angela Pinot de Moira, Sido Haakma, Katrine Strandberg-Larsen, Esther van Enckevort, Marjolein Kooijman, et al.. The EU Child Cohort Network’s core data: establishing a set of findable, accessible, interoperable and re-usable (FAIR) variables. European Journal of Epidemiology, 2021, 36 (5), pp.565-580. ⟨10.1007/s10654-021-00733-9⟩. ⟨hal-03241847⟩



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