Fosfomycin-trometamol (FT) or fluoroquinolone (FQ) as single-dose prophylaxis for transrectal ultrasound-guided prostate biopsy (TRUS-PB): A prospective cohort study

Tristan Delory (1, 2) , Annabelle Goujon (3) , Alexandra Masson-Lecomte (3) , Pauline Arias (4) , Anthony Laurancon-Fretar (1) , Béatrice Bercot (4) , Pierre Mongiat-Artus (3, 4) , Jean-Michel Molina (1) , Matthieu Lafaurie (1)

1 Service de maladies infectieuses et tropicales [Saint-Louis]
2 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
3 Service d'Urologie [CHU Saint-Louis]
4 Service de microbiologie [Saint-Louis]

Objectives: The increasing incidence of fluoroquinolones (FQ) resistance may lower its efficacy in preventing UTI following transrectal ultrasound-guided prostate biopsy (TRUS-PB). We assessed the efficacy and safety of FQ and fosfomycin-trometamol (FT) in patients undergoing TRUS-PB. Methods: A prospective observational study was conducted between April 2017 and June 2019 and enrolled men undergoing TRUS-PB and receiving a single-dose of FQ (FQ-arm) or FT (FT-arm) for UTI prophylaxis per physician's choice. The primary efficacy endpoint was self-reported TRUS-PB UTI. We assessed baseline factors associated with UTI with logistic regression. Results: A total of 222 men were enrolled, 141/222 (64%) received FQ, and 81/222 (36%) FT. The median age was 67.6 years [IQR, 61.4-72.1] and the Charlson score was 3 [IQR, 3-5]. The overall incidence of self-reported TRUS-PB UTI was 12% (24/197, (95%CI, 8%-17%)): 15% (17/116, (95% CI, 10%-17%)) in FQ-arm, versus 9% (7/81, 95% CI (5%-13%)) in FT-arm (RR = 0.55 (95% CI, 0.22-1.40), p-value = 0.209). No baseline characteristic was significantly associated with TRUS-PB UTI. Safety was similar between the arms: the rate of the reported adverse event was 31% (36/116, (95% CI, 25%-37%) in the FQ-arm versus 36% (28/81, (95% CI, 28%-41%)) in the FT-arm (RR = 1.17 (95% CI, 0.64-2.15), p = 0.602). Conclusions: TRUS-PB UTI prophylaxis with FT and FQ has similar efficacy and safety. A randomized comparison of these two antibiotics is warranted.

Mots clés: Cohort study; Fluoroquinolones; Fosfomycin; Prophylaxis; Prostate Biopsy

Domaines: Sciences du Vivant [q-bio]

Tristan Delory, Annabelle Goujon, Alexandra Masson-Lecomte, Pauline Arias, Anthony Laurancon-Fretar, et al.. Fosfomycin-trometamol (FT) or fluoroquinolone (FQ) as single-dose prophylaxis for transrectal ultrasound-guided prostate biopsy (TRUS-PB): A prospective cohort study. International Journal of Infectious Diseases, 2021, 102, pp.269-274. ⟨10.1016/j.ijid.2020.10.065⟩. ⟨hal-03160885⟩