L. A. Matsuda, S. J. Lolait, M. J. Brownstein, A. C. Young, and T. Bonner, Structure of a cannabinoid receptor and functional expression of the cloned cDNA, Nature, vol.346, pp.561-565, 1990.

W. A. Devane, L. Hanus, and A. Breuer, Isolation and structure of a brain constituent that binds to the cannabinoid receptor, Science, vol.258, pp.1946-1955, 1992.

S. Munro, K. L. Thomas, and M. Abu-shaar, Molecular characterization of a peripheral receptor for cannabinoids, Nature, vol.365, pp.61-66, 1993.

E. Fride, Endocannabinoids in the central nervous system-an overview, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.66, pp.221-254, 2002.

L. Hanus, A. Gopher, S. Almog, and R. Mechoulam, Two new unsaturated fatty acid ethanolamides in the brain that bind to the cannabinoid receptor, J Med Chem, vol.36, pp.3032-3036, 1993.

R. Mechoulam, S. Ben-shabat, and L. Hanus, identification of an endogenous 2-monoglyceride

, Biochem Pharmacol, vol.50, pp.83-90, 1995.

L. Hanus, S. Abu-lafi, and E. Fride, 2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor, Proc Natl Acad Sci, vol.98, pp.3662-3667, 2001.

A. C. Kreitzer and W. G. Regehr, Retrograde signaling by endocannabinoids, Curr Opin Neurobiol, vol.12, pp.324-354, 2002.

I. Llano, N. Leresche, and A. Marty, Calcium entry increases the sensitivity of cerebellar Purkinje cells to applied GABA and decreases inhibitory synaptic currents, Neuron, vol.6, pp.565-74, 1991.

T. A. Pitler and B. E. Alger, Postsynaptic spike firing reduces synaptic GABAA responses in hippocampal pyramidal cells, J Neurosci, vol.12, pp.4122-4154, 1992.

D. Robbe, G. Alonso, F. Duchamp, J. Bockaert, and O. J. Manzoni, Localization and mechanisms of action of cannabinoid receptors at the glutamatergic synapses of the mouse nucleus accumbens, J Neurosci, vol.21, pp.109-125, 2001.

D. Robbe, M. Kopf, A. Remaury, J. Bockaert, and O. J. Manzoni, Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens, Proc Natl Acad Sci, vol.99, pp.8384-8392, 2002.

J. Doherty and R. Dingledine, Functional interactions between cannabinoid and metabotropic glutamate receptors in the central nervous system, Curr Opin Pharmacol, vol.3, pp.46-53, 2003.

G. L. Gerdeman, J. Ronesi, and D. M. Lovinger, Postsynaptic endocannabinoid release is critical to long-term depression in the striatum, Nat Neurosci, vol.5, pp.446-51, 2002.

G. Marsicano, C. T. Wotjak, and S. C. Azad, The endogenous cannabinoid system controls extinction of aversive memories, Nature, vol.418, pp.530-534, 2002.

B. Costa, S. Vailati, and M. Colleoni, SR 141716A, a cannabinoid receptor antagonist, reverses the behavioural effects of anandamide-treated rats, Behav Pharmacol, vol.10, pp.327-358, 1999.

W. L. Dewey, Cannabinoid pharmacology, Pharmacol Rev, vol.38, pp.151-78, 1986.

C. Ledent, O. Valverde, and G. Cossu, Unresponsivenes to cannabinoids and feduced addictive effects of opiates in CB1 receptor knockout mice, Science, vol.283, p.15, 1999.

R. G. Pertwee, Cannabinoid receptors and pain, Prog Neurobiol, vol.63, pp.569-611, 2001.

S. P. Welch, J. W. Huffman, and J. Lowe, Differential blockade of the antinociceptive effects of centrally administered cannabinoids by SR141716A, J Pharmacol Exp Ther, vol.286, pp.1301-1309, 1998.

A. Calignano, L. Rana, G. Giuffrida, A. Piomelli, and D. , Control of pain initiation by endogenous cannabinoids, Nature, vol.394, pp.277-281, 1998.

D. L. Misner and J. M. Sullivan, Mechanism of cannabinoid effects on long-term potentiation and depression in hippocampal CA1 neurons, J Neurosci, vol.19, pp.6795-805, 1999.

N. Stella, P. Schweitzer, and D. Piomelli, A second endogenous cannabinoid that modulates long-term potentiation, Nature, vol.388, pp.773-781, 1997.

M. Reibaud, M. C. Obinu, C. Ledent, M. Parmentier, G. A. Bohme et al., Enhancement of memory in cannabinoid CB1 receptor knock-out mice, Eur J Pharmacol, vol.379, pp.1-2, 1999.

E. Murillo-rodriguez, M. Sanchez-alavez, L. Navarro, D. Martinez-gonzalez, R. Drucker-colin et al., Anandamide modulates sleep and memory in rats, Brain Res, vol.812, pp.270-274, 1998.

A. Chakrabarti, J. E. Ekuta, and E. S. Onaivi, Neurobehavioral effects of anandamide and cannabinoid receptor gene expression in mice, Brain Res Bull, vol.45, pp.67-74, 1998.

F. Berrendero and R. Maldonado, Involvement of the opioid system in the anxiolytic-like effects induced by ? 9 -tetrahydrocannabinol, Psychopharmacology, vol.163, pp.111-118, 2002.

K. A. Miczek, Delta9-tetrahydrocannabinol: Antiagressive effects in mice, rats, and squirrel monkeys, Science, vol.199, pp.1459-61, 1978.

F. Rodriguez-de-fonseca, M. Navarro, and R. Gómez, An anorexic lipid mediator regulated by feeding, Nature, vol.414, pp.209-221, 2001.

J. M. Walker, S. M. Huang, and . Cannabinoid,

, Pharmacol Ther, vol.95, pp.127-162, 2002.

W. Hamann and P. P. Di-vadi, Analgesic effect of the cannabinoid analogue nabilone is not mediated by opioid receptors, Lancet, vol.353, p.560, 1999.

T. Jarvinen, D. W. Pate, and K. Laine, Cannabinoids in the treatment of glaucoma, Pharmacol Ther, vol.95, pp.203-223, 2002.

E. M. Berry and R. Mechoulam, Tetrahydrocannabinol and endocannabinoids in feeding and appetite, Pharmacol Ther, vol.95, pp.185-90, 2002.

D. Piomelli, A. Giuffrida, A. Calignano, and F. Rodriguez-de-fonseca, The endocannabinoid system as a target for therapeutic drugs, Trends Pharmacol Sci, vol.21, pp.218-242, 2000.

J. Romero, I. Lastres-becker, and R. De-miguel, The endogenous cannabinoid system and the basal ganglia. Biochemical, pharmacological, and therapeutic aspects

, Pharmacol Ther, vol.95, pp.137-52, 2002.

R. G. Pertwee, Cannabinoids and multiple sclerosis, Pharmacol Ther, vol.95, pp.165-74, 2002.

M. Van-der-stelt, W. B. Veldhuis, and M. Maccarrone, Acute neuronal injury, excitotoxicity, and the endocannabinoid system

, Mol Neurobiol, vol.26, pp.317-363, 2002.

. Tirés-À-part-l and . Venance,