Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses

Neil Murphy (1, 2) , Robert Carreras-Torres , Mingyang Song , Andrew Chan , Richard Martin , Nikos Papadimitriou (2) , Niki Dimou (2) , Konstantinos Tsilidis (3) , Barbara Banbury , Kathryn Bradbury (4) , Jelena Besevic , Sabina Rinaldi (5, 2) , Elio Riboli (6) , Amanda Cross (6) , Ruth Travis (7) , Claudia Agnoli (8) , Demetrius Albanes (9) , Sonja I Berndt (10) , Stéphane Bézieau (11, 12) , D. Timothy Bishop (13) , Hermann Brenner (14) , Daniel Buchanan , N. Charlotte Onland-Moret (15) , Andrea Burnett-Hartman , Peter J Campbell (16) , Graham Casey (17) , Sergi Castellví-Bel , Jenny Chang-Claude (18) , María-Dolores Chirlaque (19) , Albert de La Chapelle (20) , Dallas R English (21) , Jane Figueiredo , Steven Gallinger (22) , Graham G Giles (23) , Stephen B. Gruber (24) , Andrea Gsur , Jochen Hampe (25) , Heather Hampel (20) , Tabitha Harrison , Michael Hoffmeister (26) , Li Hsu , Wen-Yi Huang (27) , Jeroen Huyghe (28) , Mark Jenkins , Temitope Keku , Tilman Kuhn (29) , Sun-Seog Kweon , Loic Le Marchand (30) , Christopher Li , Li Li (31) , Annika Lindblom (32) , Vicente Martín (33) , Roger L Milne (21) , Víctor Moreno (34) , Polly Newcomb , Kenneth Offit (35) , Shuji Ogino (36) , Jennifer Ose , Vittorio Perduca (37, 38, 39) , Amanda Phipps , Elizabeth Platz (40) , John Potter , Conghui Qu , Gad Rennert (41) , Lori Sakoda , Clemens Schafmayer (42) , Robert Schoen , Martha Slattery , Catherine M Tangen (43) , Cornelia Ulrich (44) , Franzel J.B. van Duijnhoven , Bethany van Guelpen (45) , Kala Visvanathan (40) , Pavel Vodicka (46) , Ludmila Vodickova , Veronika Vymetalkova , Hansong Wang , Emily White , Alicja Wolk (47) , Michael Woods , Anna Wu , Wei Zheng (48) , Ulrike Peters , Marc J Gunter (1)

1 Nutrition and Metabolism Section
2 CIRC - Centre international de Recherche sur le Cancer
3 School of Public Health - Department of Epidemiology and Biostatistics
4 Nuffield Department of Population Health - Cancer Epidemiology Unit
5 IACR - International Agency for Cancer Research
6 Faculty of Medicine - School of Public Health [London, UK]
7 University of Oxford
8 IRCCS - Candiolo Cancer Institute
9 NCI-NIH - National Cancer Institute [Bethesda]
10 Division of Cancer Epidemiology and Genetics [Bethesda, MD, États-Unis]
11 Interactions récepteurs ligands en immunocancérologie et immunopathologie
12 Service de génétique médicale - Unité de génétique clinique [Nantes]
13 St. James's University Hospital
14 Division of Clinical Epidemiology and Aging Research
15 University Medical Center [Utrecht]
16 The Cancer, Ageing and Somatic Mutation Programme [Cambridgeshire, UK]
17 Department of Preventive Medicine
18 Division of Cancer Epidemiology
19 CIBERESP - Consorcio de Investigación Biomédica en Red especializado en Epidemiología y Salud Pública
20 OSU - Ohio State University [Columbus]
21 Cancer Epidemiology Centre
22 Samuel Lunenfeld Research Institute
23 University of Melbourne
24 Department of Internal Medicine, Epidemiology, Human Genetics
25 Medical Department 1 [Dresden, Germany]
26 FESTO
27 Division of Cancer Epidemiology and Genetics
28 Department of Medical Genetics
29 Division of Cancer Epidemiology
30 UHM - University of Hawai‘i [Mānoa]
31 Chinese Center for Disease Control and Prevention
32 Department of Clinical Genetics
33 Dell-EMC
34 Biomedical Research Centre Network for Rare Diseases
35 Memorial Sloane Kettering Cancer Center [New York]
36 Department of Pathology
37 CESP - Centre de recherche en épidémiologie et santé des populations
38 IGR - Institut Gustave Roussy
39 MAP5 - UMR 8145 - Mathématiques Appliquées Paris 5
40 Johns Hopkins Bloomberg School of Public Health [Baltimore]
41 Department of Community Medicine and Epidemiology
42 Department of Visceral and Thoracic Surgery [Kiel, Germany]
43 FHCRC - Fred Hutchinson Cancer Research Center [Seattle]
44 GEOMAR - Helmholtz Centre for Ocean Research [Kiel]
45 Department of Medical Biosciences and Pathology
46 Institute of Experimental Medicine
47 Karolinska Institutet [Stockholm]
48 Center for Astrophysical Sciences [Baltimore]

Domains: Life Sciences [q-bio]; Santé publique et épidémiologie

Neil Murphy, Robert Carreras-Torres, Mingyang Song, Andrew Chan, Richard Martin, et al.. Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses. Gastroenterology, 2020, 158 (5), pp.1300-1312.e20. ⟨10.1053/j.gastro.2019.12.020⟩. ⟨hal-02872368⟩