Rivaroxaban compared with standard anticoagulants for the treatment of acute venous thromboembolism in children: a randomised, controlled, phase 3 trial

Christoph Male (1) , Anthonie Lensing , Joseph Palumbo , Riten Kumar , Ildar Nurmeev , Kerry Hege , Damien Bonnet (2) , Philip Connor , Hélène Hooimeijer , Marcela Torres , Anthony Chan , Gili Kenet , Susanne Holzhauer , Amparo Santamaría , Pascal Amedro (3, 4) , Elizabeth Chalmers , Paolo Simioni , Rukhmi Bhat , Donald Yee , Olga Lvova , Jan Beyer-Westendorf (5) , Tina Biss , Ida Martinelli , Paola Saracco , Marjolein Peters (6) , Krisztián Kállay , Cynthia Gauger , M Patricia Massicotte , Guy Young , Akos Pap , Madhurima Majumder , William Smith , Jürgen Heubach , Scott Berkowitz , Kirstin Thelen , Dagmar Kubitza , Mark Crowther (7) , Martin Prins , Paul Monagle , Angelo Molinari , Ulrike Nowak Göttl , Juan Chain , Jeremy Robertson , Katharina Thom , Werner Streif , Rudolf Schwarz , Klaus Schmitt , Gernot Grangl , An van Damme (8) , Philip Maes (9) , Veerle Labarque , Antonio Petrilli , Sandra Loggeto , Estela Azeka , Leonardo Brandao , Doan Le , Christine Sabapathy , Paola Giordano , Runhui Wu , Jie Ding , Wenyan Huang , Jianhua Mao , Päivi Lähteenmäki , Stéphane Decramer (10) , Toralf Bernig , Martin Chada , Godfrey Chan , Krisztian Kally , Beatrice Nolan , Shoshana Revel-Vilk (11) , Hannah Tamary (12) , Carina Levin , Daniela Tormene , Maria Abbattista , Andrea Artoni , Takanari Ikeyama , Ryo Inuzuka , Satoshi Yasukochi , Michelle Morales Soto , Karina Solis Labastida , Monique Suijker , Marike Bartels , Rienk Tamminga , C Heleen van Ommen , D. Maroeska Te Loo , Rui Anjos (13) , Lyudmila Zubarovskaya , Natalia Popova , Elena Samochatova , Margarita Belogurova , Pavel Svirin , Tatiana Shutova , Vladimir Lebedev (14) , Olga Barbarash , Pei Koh , Joyce Mei , Ludmila Podracka , Rubén Berrueco (15) , Maria P. Fernandez , Tony Frisk , Sebastian Grunt , Johannes Rischewski , Manuela Albisetti-Pedroni , Ali Antmen , Huseyin Tokgoz , Zeynep Karakas , Jayashree Motwani , Michael Williams , John Grainger , Jeanette Payne , Mike Richards (16) , Susan Baird , Neha Bhatnagar , Angela Aramburo , Shelley Crary , Tung Wynn , Shannon Carpenter , Sanjay Ahuja , Neil Goldenberg , Gary Woods , Kamar Godder , Ajovi Scott-Emuakpor , Gavin Roach , Leslie Raffini , Nirmish Shah , Sanjay Shah , Courtney Thornburg , Ayesha Zia , Roger Berkow

1 Medizinische Universität Wien = Medical University of Vienna
2 CMR-M3C
3 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
4 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
5 DRESDEN - CGCU - Carl Gustav Carus University
6 Pediatric Hematology
7 Department of Medicine
8 Department of Earth and Environmental Sciences [Leuven-Heverlee]
9 Service de Pédiatrie [HU Antwerp, Belgium]
10 Service de Pédiatrie - Néphrologie, Médecine interne, Hypertension
11 Pediatric Hematology/Oncology Department
12 Pediatric Hematology Unit - Pediatric Hematology Unit
13 Hospital de Santa Cruz
14 Institute for Information Transmission Problems
15 Department of Paediatric Haematology
16 Department of Human Evolution [Leipzig]

Treatment of venous thromboembolism in children is based on data obtained in adults with little direct documentation of its efficacy and safety in children. The aim of our study was to compare the efficacy and safety of rivaroxaban versus standard anticoagulants in children with venous thromboembolism.

Domaines: Sciences du Vivant [q-bio]

Christoph Male, Anthonie Lensing, Joseph Palumbo, Riten Kumar, Ildar Nurmeev, et al.. Rivaroxaban compared with standard anticoagulants for the treatment of acute venous thromboembolism in children: a randomised, controlled, phase 3 trial. The Lancet Haematology, 2019, 7 (1), ⟨10.1016/S2352-3026(19)30219-4⟩. ⟨hal-02357722⟩