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Journal articles
The steroid receptor RNA activator is the first functional RNA encoding a protein
Abstract : The steroid receptor RNA activator (SRA) has previously been characterized as belonging to the growing family of functional non-coding RNAs. However, we recently reported the Western blot detection of a putative endogenous SRA protein (SRAP) in breast cancer cells. Herein, we successfully suppressed the expression of this protein through specific RNA interference assay, unequivocally confirming its existence. Moreover, using database searches and Western blot analysis, we also showed that SRAP is highly conserved among chordata. Overall, our results suggest that SRA is the first example of a new class of functional RNAs also able to encode a protein.
Cited literature [13 references]
https://hal-univ-paris.archives-ouvertes.fr/hal-02127389
Contributor : Florent Hube Connect in order to contact the contributor
Submitted on : Tuesday, May 21, 2019 - 1:50:56 PM
Last modification on : Thursday, October 1, 2020 - 9:33:13 AM
Contributor : Florent Hube Connect in order to contact the contributor
Submitted on : Tuesday, May 21, 2019 - 1:50:56 PM
Last modification on : Thursday, October 1, 2020 - 9:33:13 AM
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