Skip to Main content Skip to Navigation
Journal articles

The steroid receptor RNA activator is the first functional RNA encoding a protein

S. Chooniedass-Kothari E. Emberley M.K. Hamedani S. Troup X. Wang 1 A. Czosnek F. Hube 2 M. Mutawe P.H. Watson E. Leygue
1 Key Laboratory of Genome Science and Information, Beijing Institute of Genomics
2 UPD7 - Université Paris Diderot - Paris 7
Abstract : The steroid receptor RNA activator (SRA) has previously been characterized as belonging to the growing family of functional non-coding RNAs. However, we recently reported the Western blot detection of a putative endogenous SRA protein (SRAP) in breast cancer cells. Herein, we successfully suppressed the expression of this protein through specific RNA interference assay, unequivocally confirming its existence. Moreover, using database searches and Western blot analysis, we also showed that SRAP is highly conserved among chordata. Overall, our results suggest that SRA is the first example of a new class of functional RNAs also able to encode a protein.
Keywords : RNA interference Steroid receptor RNA activator homologue Steroid receptor RNA activator protein Steroid receptor RNA activator Non-coding RNA
Document type :
Journal articles
Complete list of metadatas

Cited literature [13 references]  Display  Hide  Download
https://hal-univ-paris.archives-ouvertes.fr/hal-02127389
Contributor : Florent Hube <>
Submitted on : Tuesday, May 21, 2019 - 1:50:56 PM
Last modification on : Thursday, October 1, 2020 - 9:33:13 AM

Links full text

openaccess

Identifiers

Collections

UNIV-PARIS7 | USPC | UNIV-PARIS

Citation

S. Chooniedass-Kothari, E. Emberley, M.K. Hamedani, S. Troup, X. Wang, et al.. The steroid receptor RNA activator is the first functional RNA encoding a protein. FEBS Letters, Wiley, 2004, 566 (1-3), pp.43-47. ⟨10.1016/j.febslet.2004.03.104⟩. ⟨hal-02127389⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

246