Circulating malignant lymphocytes from Sezary syndrome express high level of glycoproteins carrying beta (1-6)N-acetylglucosamine-branched N-linked oligosaccharides.

C. Derappe (1) , G. Haentjens (1) , S. Lemaire (1) , J Feugeas , V. Pasqualetto (2, 1) , A Bussel , M. Aubery (1) , D. Néel (1)

1 Inserm U180 - Biologie et pathologie moléculaires des glycoprotéines
2 UPD5 - Université Paris Descartes - Paris 5

The circulating forms of malignant cells from patients with Sezary syndrome exhibit on their glycoproteins a high level of beta (1-6)GlcNAc-branched N-linked oligosaccharides, a particular species of glycans related to the metastatic potential of several tumors and T lymphocytes activation. An increased activity of the N-acetylglucosaminyltransferase V and of the beta (1-4)galactosyltransferase, two enzymes implicated in beta (1-6)GlcNAc-branching is also found. Nevertheless, contrary to activated normal T lymphocytes, Sezary lymphocytes in agreement with their non-proliferating state, do not exhibit increased thymidine uptake. This result suggests that expression of the beta (1-6)GlcNAc-branched N-linked carbohydrates could be related to some of the malignant properties of Sezary lymphocytes.

Domaines: Biochimie, Biologie Moléculaire

C. Derappe, G. Haentjens, S. Lemaire, J Feugeas, V. Pasqualetto, et al.. Circulating malignant lymphocytes from Sezary syndrome express high level of glycoproteins carrying beta (1-6)N-acetylglucosamine-branched N-linked oligosaccharides.. Leukemia, 1996, 10 (1), pp.138-41. ⟨hal-01996974⟩