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The thymus exports long-lived fully committed T cell precursors that can colonize primary lymphoid organs

Abstract : Thymic export of cells is believed to be restricted to mature T cells. Here we show that the thymus also exports fully committed T cell precursors that colonize primary lymphoid organs. These precursor cells exited the thymus before T cell receptor rearrangements and colonized lymphoid organs such as the thymus and the gut. Migration of the thymic T cell–committed precursors led to permanent colonization of the gut precursor compartment, improved the capacity of gut precursors to further differentiate into T cells and was sufficient for the generation of 'euthymic like' CD8αα+ intraepithelial lymphocytes. These data demonstrate a new function for the thymus in peripheral seeding with T cell precursors that become long lived after thymus export.
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https://hal-univ-paris.archives-ouvertes.fr/hal-01996470
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Submitted on : Monday, January 28, 2019 - 2:13:09 PM
Last modification on : Thursday, October 1, 2020 - 9:46:45 AM

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Florence Lambolez, Marie-Laure Arcangeli, Anne-Marie Joret, Valerie Pasqualetto, Corinne Cordier, et al.. The thymus exports long-lived fully committed T cell precursors that can colonize primary lymphoid organs. Nature Immunology, Nature Publishing Group, 2006, 7 (1), pp.76-82. ⟨10.1038/ni1293⟩. ⟨hal-01996470⟩

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