Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination - Archive ouverte HAL Access content directly
Journal Articles Journal of Experimental Medicine Year : 2023

Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination

(1) , (2, 3) , (1, 4) , (5) , (6, 4) , (6, 4) , (6, 4) , (7) , (2) , , , (5) , , , , (8, 9) , (10, 11) , , (12) , (13) , (13) , (14) , (15) , (16) , (17) , (18) , (19) , (20) , , (21) , (22) , (23, 11, 24) , (25) , (26, 27) , (28) , (28) , (28) , (2, 29) , , (30) , , , , , , , (5) , , , (31, 27) , (2, 29, 3, 32) , (1, 4)
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
Aurélien Sokal
Magali Bouvier-Alias
Imane Azzaoui
Andréa de la Selle
Qian Zhang
Lucy Bizien
Anya Rothenbuhler
Nathalie Cheikh
Juliane Léger
Jean-Christophe Goffard
Caroline Storey
Caroline Demily
Coralie Mallebranche
Jane Peake
Laetitia Languille
Bertrand Boisson
Sébastien Gallien
Bénédicte Neven
Marc Michel
  • Function : Author
Bertrand Godeau
Laurent Abel
Felix Rey
Jean-Claude Weill
Claude-Agnès Reynaud

Abstract

Inborn and acquired deficits of type I interferon (IFN) immunity predispose to life-threatening COVID-19 pneumonia. We longitudinally profiled the B cell response to mRNA vaccination in SARS-CoV-2 naive patients with inherited TLR7, IRF7, or IFNAR1 deficiency, as well as young patients with autoantibodies neutralizing type I IFNs due to autoimmune polyendocrine syndrome type-1 (APS-1) and older individuals with age-associated autoantibodies to type I IFNs. The receptor-binding domain spike protein (RBD)–specific memory B cell response in all patients was quantitatively and qualitatively similar to healthy donors. Sustained germinal center responses led to accumulation of somatic hypermutations in immunoglobulin heavy chain genes. The amplitude and duration of, and viral neutralization by, RBD-specific IgG serological response were also largely unaffected by TLR7, IRF7, or IFNAR1 deficiencies up to 7 mo after vaccination in all patients. These results suggest that induction of type I IFN is not required for efficient generation of a humoral response against SARS-CoV-2 by mRNA vaccines.
Fichier principal
Vignette du fichier
jem_20220258.pdf (4.01 Mo) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

pasteur-03847416 , version 1 (10-11-2022)

Licence

Attribution - NonCommercial - ShareAlike - CC BY 4.0

Identifiers

Cite

Aurélien Sokal, Paul Bastard, Pascal Chappert, Giovanna Barba-Spaeth, Slim Fourati, et al.. Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination. Journal of Experimental Medicine, 2023, 220 (1), pp.e20220258. ⟨10.1084/jem.20220258⟩. ⟨pasteur-03847416⟩
0 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More