Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination - Université de Paris - Faculté de Santé Accéder directement au contenu
Article Dans Une Revue Journal of Experimental Medicine Année : 2023

Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination

1 INEM - UM 111 (UMR 8253 / U1151) - Institut Necker Enfants-Malades
2 Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)
3 Rockefeller University [New York]
4 IMRB - Institut Mondor de Recherche Biomédicale
5 Virologie Structurale - Structural Virology
6 CHU Henri Mondor [Créteil]
7 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
8 INSERM U955, team 2. Mondor Biomedical Research Institute, Paris-Est Créteil University, Créteil, France. Departement of Internal Medicine, Henri Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Est Créteil University, Créteil, France
9 CHU Angers - Centre Hospitalier Universitaire d'Angers
10 UA - Université d'Angers
11 AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)
12 Université Paris-Saclay
13 HNFC - Hôpital Nord Franche-Comté [Hôpital de Trévenans]
14 Service de pédiatrie [CHRU Besançon]
15 GHU AP-HP Nord - Université Paris Cité
16 Hôpital Lariboisière-Fernand-Widal [APHP]
17 CHU Nancy - Centre Hospitalier Universitaire de Nancy
18 Hôpital Mère-Enfant [Hôpital Hôtel Dieu, Nantes]
19 ULB - Université libre de Bruxelles
20 Hôpital Robert Debré
21 Centre Hospitalier le Vinatier [Bron]
22 Hospital Universitario Infanta Leonor [Madrid]
23 IDIBELL - Institut d'Investigació Biomèdica de Bellvitge = Bellvitge Biomedical Research Institute
24 UPCité - Université Paris Cité
25 UVSQ - Université de Versailles Saint-Quentin-en-Yvelines
26 EFS - Etablissement Français du Sang [La Plaine Saint-Denis]
27 Sydney Children's hospital
28 UNSW - University of New South Wales [Sydney]
29 CHQ - Children’s Health Queensland [Brisbane]
30 Hôpital Necker - Enfants Malades [AP-HP]
31 Universidad Fernando Pessoa Canarias [Las Palmas de Gran Canaria, Spain]
32 Garvan Institute of medical research
33 HHMI - Howard Hughes Medical Institute [New York]
Aurélien Sokal
Magali Bouvier-Alias
Andréa de la Selle
Qian Zhang
Lucy Bizien
Anya Rothenbuhler
Nathalie Cheikh
Juliane Léger
Jean-Christophe Goffard
Caroline Storey
Caroline Demily
Coralie Mallebranche
Jane Peake
Laetitia Languille
Bertrand Boisson
Sébastien Gallien
Bénédicte Neven
Marc Michel
  • Fonction : Auteur
Bertrand Godeau
Laurent Abel
Felix Rey
Jean-Claude Weill
Claude-Agnès Reynaud

Résumé

Inborn and acquired deficits of type I interferon (IFN) immunity predispose to life-threatening COVID-19 pneumonia. We longitudinally profiled the B cell response to mRNA vaccination in SARS-CoV-2 naive patients with inherited TLR7, IRF7, or IFNAR1 deficiency, as well as young patients with autoantibodies neutralizing type I IFNs due to autoimmune polyendocrine syndrome type-1 (APS-1) and older individuals with age-associated autoantibodies to type I IFNs. The receptor-binding domain spike protein (RBD)–specific memory B cell response in all patients was quantitatively and qualitatively similar to healthy donors. Sustained germinal center responses led to accumulation of somatic hypermutations in immunoglobulin heavy chain genes. The amplitude and duration of, and viral neutralization by, RBD-specific IgG serological response were also largely unaffected by TLR7, IRF7, or IFNAR1 deficiencies up to 7 mo after vaccination in all patients. These results suggest that induction of type I IFN is not required for efficient generation of a humoral response against SARS-CoV-2 by mRNA vaccines.
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Dates et versions

pasteur-03847416 , version 1 (10-11-2022)

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Paternité - Pas d'utilisation commerciale - Partage selon les Conditions Initiales

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Aurélien Sokal, Paul Bastard, Pascal Chappert, Giovanna Barba-Spaeth, Slim Fourati, et al.. Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination. Journal of Experimental Medicine, 2023, 220 (1), pp.e20220258. ⟨10.1084/jem.20220258⟩. ⟨pasteur-03847416⟩
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