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Journal articles
Visible light amination/Smiles cascade: access to phthalazine derivatives
Abstract : We report the synthesis of various phthalazines via a new cascade reaction, initiated by visible light photocatalysis, involving a radical hydroamination reaction followed by a radical Smiles rearrangement. Phthalazine derivatives are obtained in high yields and from a broad scope readily accessible ortho-alkynylsulfonohydrazone precursors. The mild photoredox conditions ensure an excellent functional group tolerance. Application of this strategy to a one-pot protocol starting from the corresponding carbonyl compounds, and subsequent functionalization allow the rapid synthesis of structurally diverse structures.
Cited literature [27 references]
https://hal-univ-paris.archives-ouvertes.fr/hal-02384218
Contributor : Etienne Brachet <>
Submitted on : Thursday, November 28, 2019 - 11:45:54 AM
Last modification on : Thursday, October 1, 2020 - 9:46:45 AM
Long-term archiving on: : Saturday, February 29, 2020 - 2:55:27 PM
Contributor : Etienne Brachet <>
Submitted on : Thursday, November 28, 2019 - 11:45:54 AM
Last modification on : Thursday, October 1, 2020 - 9:46:45 AM
Long-term archiving on: : Saturday, February 29, 2020 - 2:55:27 PM
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