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Simultaneous positron emission tomography and ultrafast ultrasound for hybrid molecular, anatomical and functional imaging

Jean Provost 1 Anikitos Garofalakis 2, 3 Joevin Sourdon 2, 3 Damien Bouda 3, 2 Béatrice Berthon 1 Thomas Viel 2, 3 Mailyn Perez-Liva 2, 3 Charlotte Lussey-Lepoutre 2, 4, 5 Judith Favier 2, 3 Mafalda Correia 1 Mathieu Pernot 1 Johanna Chiche 6 Jacques Pouysségur 7, 8 Mickaël Tanter 1, * Bertrand Tavitian 2, 3, 9, *
* Corresponding author
1 Institut Langevin ondes et images
2 PARCC - UMR-S U970 - Paris-Centre de Recherche Cardiovasculaire
3 UPD5 Médecine - Université Paris Descartes - Faculté de Médecine
4 UPMC - Université Pierre et Marie Curie - Paris 6 - UFR de Médecine Pierre et Marie Curie
5 CHU Pitié-Salpêtrière [AP-HP]
6 INSERM U1065 - C3M - Equipe “Contrôle Métabolique des Morts Cellulaires”
C3M - Centre méditerranéen de médecine moléculaire
7 IRCAN - Institut de Recherche sur le Cancer et le Vieillissement
8 Département de Biologie Médicale [Centre Scientifique de Monaco]
9 Département de Radiologie Cardiovasculaire [AP-HP Hôpital Européen Georges Pompidou]
Abstract : Positron emission tomography–computed tomography (PET–CT) is the most sensitive molecular imaging modality, but it does not easily allow for rapid temporal acquisition. Ultrafast ultrasound imaging (UUI)—a recently introduced technology based on ultrasonic holography—leverages frame rates of up to several thousand images per second to quantitatively map, at high resolution, haemodynamic, biomechanical, electrophysiological and structural parameters. Here, we describe a pre-clinical scanner that registers PET–CT and UUI volumes acquired simultaneously and offers multiple combinations for imaging. We demonstrate that PET–CT–UUI allows for simultaneous images of the vasculature and metabolism during tumour growth in mice and rats, as well as for synchronized multi-modal cardiac cine-loops. Combined anatomical, functional and molecular imaging with PET–CT–UUI represents a high-performance and clinically translatable technology for biomedical research.
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Submitted on : Wednesday, August 29, 2018 - 3:50:21 PM
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UNIV-PARIS5 | CNRS | UNIV-PARIS7 | USPC | UNICE | PARISTECH | UNIV-COTEDAZUR | SORBONNE-UNIVERSITE | LANGEVIN | SU-SCIENCES | UNIV-PARIS | UP-SANTE | UP-SCIENCES | PSL | ESPCI-PSL | ESPCI | IL | SU-TI

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Jean Provost, Anikitos Garofalakis, Joevin Sourdon, Damien Bouda, Béatrice Berthon, et al.. Simultaneous positron emission tomography and ultrafast ultrasound for hybrid molecular, anatomical and functional imaging. Nature Biomedical Engineering, Nature Publishing Group, 2018, 2, pp.85-94. ⟨10.1038/s41551-018-0188-z⟩. ⟨hal-01864270⟩

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